Two art-centric home office ideas

I work outside my home, as does my husband, so there's no reason to use any of  the limited space we have for a home office. I've always loved the idea of decorating one, though. I've had two home office "designs" in my head for years, both of which revolve around art. (Of course they do.)

Home office design #1: Hogarth's Industry and Idleness

William Hogarth was an 18th Century artist and social critic known for his moral commentary and satire. Industry and Idleness is a set of 12 engravings telling the stories of two young men who start off as apprentices in the same shop. Over the course of the panels, the industrious young man marries the boss's daughter, becomes a magistrate and ultimately Lord Mayor of London. The lazy young man digs into every possible bad deed (Theft! Gambling! Prostitution! You name it!) and is eventually sent to the gallows to pay for his crimes. It is a super heavy handed, black-and-white view of morality--one I don't subscribe to, certainly. But I thoroughly enjoy Hogarth's use of details to tell the stories; there are so many "Easter eggs" to discover as you examine the panels. I love the idea of framing the complete set in 2x6 or 3x4 grid in an office, as a sort of tongue-in-cheek reminder to keep hustling.

I'd frame prints of the series and display them prominently and traditionally as such:

Home office design #2: Gallery of portraits

I know they're not for everyone, but I adore quirky portraits, and I have long fantasized about doing a gallery wall full of them in a home office. I'd refer to them as my "co-workers" and then chuckle at myself, as there wouldn't actually be anyone else around to laugh.

For this design, I'd hang them in a looser, more eclectic gallery wall, like these:

Design-wise the two ideas feel very different. But I like art and interior design that doesn't take itself too seriously, and I think both of these would fit nicely with my sense of humor.

Collectors, what fantasy rooms have you designed around art?